Description
EDIL3，also known as Del1, is a novel extracellular matrix protein encoding three Notch-like epidermal growth factor repeats, an RGD motif, and two discoidin domains.
EDIL3 is expressed in an endothelial cell-restricted pattern during early development.
EDIL3 might involves autocrine angiogenic pathway for the embryonic endothelium, and this function is mediated in part by productive ligation of integrin alpha V beta 3.
Overall, EDIL3 plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development.
Moreover, It also influences endothelial cell behavior